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Glucocorticoid for Covid-19 update

Why are corticosteroids considered for treatment?

In the early days of the SARS-CoV-2 pandemic, based on experience in both SARS and MERS, recommendations [1] cautioned against the use of systemic corticosteroids due to risk of worsening clinical status, delayed viral clearance, and adverse events [2-4]. Given the hyper-inflammatory state in COVID-19, immunomodulatory approaches, including steroids, continue to be evaluated to address both ARDS and systemic inflammation. ARDS stemming from dysregulated systemic inflammation may translate into prolonged ventilatory requirements and in-hospital mortality. In non-viral ARDS settings, there is increasing support for the role of steroids in the management of ARDs

A recent multicenter RCT in patients with moderate to severe ARDS demonstrated a reduced number of ventilatory days and reduction in mortality with use of a 10-day regimen of dexamethasone

The RECOVERY trial is a randomized trial among hospitalized patients in the United Kingdom . In that study, 2,104 participants were randomized to receive dexamethasone (6 mg daily for up to 10 days) and 4,321 were randomized to usual care. The RECOVERY trial reported on the outcomes of mortality and hospital discharge. Participants and study staff were not blinded to the treatment arms.

Benefits

Critical illness

Among hospitalized, critically ill patients, the odds of mortality at 28 days was 34% less among patients treated with glucocorticoids than among patients not treated with glucocorticoids (OR: 0.66; 95% CI: 0.54; 0.82; high CoE). In addition, at 28 days, patients receiving dexamethasone were more likely to be discharged from the hospital (RR: 1.11; 95% CI: 1.04, 1.19; moderate CoE).

Recommendation 7Among hospitalized critically ill patients* with COVID-19, the IDSA guideline panel recommends dexamethasone rather than no dexamethasone. (Strong recommendation, Moderate certainty of evidence)

  • Remark: If dexamethasone is unavailable, equivalent total daily doses of alternative glucocorticoids may be used. Dexamethasone 6 mg IV or PO for 10 days (or until discharge) or equivalent glucocorticoid dose may be substituted if dexamethasone unavailable. Equivalent total daily doses of alternative glucocorticoids to dexamethasone 6 mg daily are methylprednisolone 32 mg and prednisone 40 mg.

Recommendation 8: Among hospitalized patients with severe**, but non-critical, COVID-19, the IDSA guideline panel suggests dexamethasone rather than no dexamethasone. (Conditional recommendation†, Moderate certainty of evidence)

  • Remark: Dexamethasone 6 mg IV or PO for 10 days (or until discharge) or equivalent glucocorticoid dose may be substituted if dexamethasone unavailable. Equivalent total daily doses of alternative glucocorticoids to dexamethasone 6 mg daily are methylprednisolone 32 mg and prednisone 40 mg.

Recommendation 9: Among hospitalized patients with mild-to-moderate*** COVID-19 without hypoxemia requiring supplemental oxygen, the IDSA guideline panel suggests against the use of glucocorticoids. (Conditional recommendation††, Low certainty of evidence)

Severity definitions:

  • *Critical illness is defined as patients on mechanical ventilation and ECMO. Critical illness includes end organ dysfunction as is seen in sepsis/septic shock. In COVID-19, the most commonly reported form of end organ dysfunction is ARDS
  • **Severe illness is defined as patients with SpO2 ≤94% on room air, including patients on supplemental oxygen.
  • ***Mild-to-moderate illness is defined as patient with a SpO2 >94% not requiring supplemental oxygen.

source

https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#Recommendations7-9:Glucocorticoids

reference

  1. RECOVERY Collaborative Group, Horby PW, Mafham M, et al. Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet 2020; 396(10259): 1345-52.
  2. World Health Organization. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Available at: https://apps.who.int/iris/bitstream/handle/10665/331446/WHO-2019-nCoV-clinical-2020.4-eng.pdf. Accessed 24 June 2020.
  3. Arabi YM, Mandourah Y, Al-Hameed F, et al. Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome. Am J Respir Crit Care Med 2018; 197(6): 757-67.
  4. Lee N, Allen Chan KC, Hui DS, et al. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol 2004; 31(4): 304-9.
  5. Xiao JZ, Ma L, Gao J, et al. [Glucocorticoid-induced diabetes in severe acute respiratory syndrome: the impact of high dosage and duration of methylprednisolone therapy]. Zhonghua Nei Ke Za Zhi 2004; 43(3): 179-82.

This secondary analysis of the COVIP study shows a higher 30-day mortality in critically ill elderly COVID-19 patients who received steroids as part of their treatment @cjungMD https://bit.ly/3xdyEur

More than a year after the onset of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, treating patients with coronavirus disease 2019 (COVID-19) remains a challenge. In contrast to the rapid development of effective vaccines against SARS-CoV-2, the development of specific and effective therapeutics against COVID-19 remains largely unresolved.

In addition to standard intensive care, including oxygen therapy and organ support when required, the use of systemic corticosteroids was found to have a positive effect in randomised trials. However, data regarding treatment of elderly COVID-19 patients are scarce.

Importantly, treatment with corticosteroids has well documented deleterious effects [1]: While the immunosuppressive effect in patients with COVID-19 is presumably responsible for the desired therapeutic effect, it may also render the patients more prone to secondary bacterial infections and potentially decrease viral clearance [2]. Corticosteroid therapy is also associated with hyperglycaemia, has catabolic effects and is associated with neuropathy. This could potentially affect the risk–benefit balance, especially in vulnerable patient groups, such as elderly, frail patients.

The aim of this secondary analysis was to investigate the effects of corticosteroid therapy in an international observational prospective study of critically ill elderly patients with COVID-19.

The COVIP study (“Corona Virus disease (COVID19) in Very Elderly Intensive care Patients (VIPs)”; NCT04321265) included patients aged 70 years or older with proven COVID-19 and admitted to an intensive care unit (ICU) [3]. 30-day mortality was defined as the primary endpoint. The study was conducted by the Very old Intensive care Patient (VIP) network [4] across 207 ICUs in 35 countries. Data were collected through an electronic case report form. A prospective study design was chosen to achieve high-quality data. Informed consent was taken if not waived by the local ethical committee.

Two multi-level logistic regression models were utilised: the first model used the hospital unit as random effect and the steroid use as fixed effect; the second model was a multi-variable model adjusting for “The Sequential Organ Failure Assessment” (SOFA) score and frailty as assessed by the Clinical Frailty Scale. Sensitivity analyses complemented the analysis.

In total, 3082 patients were included in the COVIP study; 2115 patients received corticosteroids, and 967 patients received none. Median age was 75 (interquartile range (IQR) 72–79) years in both groups. With a median SOFA score of 5 (IQR 3–8), there was no difference between the two groups.

30-day mortality was 53% in the group treated with corticosteroids and 42% in the no-corticosteroid group (p<0.001).

The univariate 30-day mortality rates were higher in patients receiving corticosteroids (53 versus 42%; aOR 1.16, 95%CI 1.28–2.02; p<0.001). This association of corticosteroid use was even more pronounced after 3 months (69% versus 49%; p<0.001; figure 1a). In addition, we found that corticosteroids remained associated with increased odds of 30-day mortality after multivariable adjustment (aOR 1.60, 95% CI 1.26–2.04; <0.001). Further sensitivity analyses consistently confirmed the finding in subgroups stratifying for age (<80/≥80 years), frailty (fit/vulnerable/frail), mechanical ventilation (yes/no), noninvasive ventilation (yes/no), sex (female/male), symptom onset (≤7 days/>7 days), and vasopressor therapy (yes/no) (figure 1b). Furthermore, in sensitivity analyses evaluating patients in the first surge (March–May, aOR 1.38, 95% CI 1.05–1.82; p=0.02; n=1448) and the second surge (September–December, aOR 2.09, 95% CI 1.04–4.21; p=0.04; n=1414) the finding was sustained.

 

In this prospective study of more than 3000 critically ill COVID-19 patients aged 70 years and older, we have found an independent association of steroid use with increased mortality.

These results question the routine use of corticosteroid treatment in elderly COVID-19 patients. While the immunosuppressive effect of steroids is undisputed and desirable in the context of severe COVID-19 treatment, the adverse effects of steroid treatment in elderly patients may outweigh the potential benefits.

This is the largest prospective analysis of critically ill elderly patients in relation to corticosteroid use to treat severe COVID-19 disease. Corticosteroid therapy has been established as standard of care in all ICU patients. However, even landmark randomised controlled trials do not support this with evidence in elderly patients. The RECOVERY study [5] showed no effect of corticosteroids in their subgroup of patients >70 years. Of note, only 169 patients in this group were on mechanical ventilation. The CoDEX study found no effect on mortality after 28 days, but no data was supplied specifically looking at patients above 70 years old [6]. Thus, both studies included far fewer patients than our current analysis. It is important to note that our data does not question the corticosteroid strategy in younger COVID-19 patients. It just emphasises that the decision to use corticosteroids needs to be individually tailored, first and foremost according to age, but also with regards to comorbidities and other factors [7].

Our analysis has limitations: First, this is a secondary analysis of a prospective study. Second, our study is not randomised and, despite multivariable adjustment, it is likely that unknown confounding factors may have contributed to our findings. Third, we have no detailed information about dosage and duration of corticosteroid treatment.

In conclusion, in this prospective observational study we found a higher 30-day mortality in critically ill elderly COVID-19 patients who received steroids as part of their treatment.

Association of early dexamethasone therapy with mortality in critically Ill COVID-19 patients: a French multicenter study

29 Oct 2022

 

Background

Dexamethasone is recommended for COVID-19 patients who require oxygen therapy. However, its effectiveness in reducing mortality and intubation, and its safety, remain debated. We aimed to investigate whether dexamethasone reduces day-28 mortality in unselected patients with critical COVID-19.

Methods

We performed an observational cohort study in consecutive COVID-19 patients admitted to any of 13 French intensive care units (ICUs) in 2020. The primary objective was to determine whether early dexamethasone therapy was associated with day-28 mortality and the secondary objectives were to assess whether early dexamethasone decreased intubation requirements and to collect adverse events.

Results

Of 1058 included patients, 611 (57.75%) received early dexamethasone (early dexamethasone group), 358 (33.83%) did not receive any steroids (no steroids group), and 89 (8.41%) received late dexamethasone or other steroids. Day-28 mortality was similar between the early dexamethasone and the no steroids groups (15.06% and 14.25%, respectively; P = 0.59). Factors associated with day-28 mortality were older age (adjusted hazard ratio [aHR], 1.06; 1.04–1.09; P < 0.001), worse SOFA score (aHR, 1.13; 1.06–1.20; P < 0.001), and immunocompromised status (aHR, 1.59; 1.01–2.50; P = 0.043). Early dexamethasone was associated with fewer intubations (48.55% vs. 61.49%, P < 0.001) and more ventilator-free days by day 28 (22 [2–28] vs. 17 [1–28] days, P = 0.003), compared to no steroids. Ventilator-associated pneumonia (VAP) was more common with early dexamethasone (HR, 1.29 [1.01–1.63], P = 0.04) than with no steroids, whereas no differences were noted for bloodstream infection, fungal infection, or gastrointestinal bleeding.

Conclusions

Early dexamethasone in critically ill COVID-19 patients was not associated with lower day-28 mortality. However, early dexamethasone was associated with lower intubation needs and more ventilator-free days by day 28. In patients treated with invasive mechanical ventilation, early dexamethasone was associated with a higher risk of VAP.

 

reference

Table 5a. Systemic Corticosteroids: Selected Clinical Data

Last Updated: January 26, 2023

The clinical trials described in this table do not represent all the trials that the Panel reviewed while developing the recommendations for systemic corticosteroids. The studies summarized below are those that have had the greatest impact on the Panel’s recommendations. Unless stated otherwise, the clinical trials listed below only included participants aged ≥18 years.

Methods Results Limitations and Interpretation
RECOVERY: Open-Label RCT of Dexamethasone in Hospitalized Patients With COVID-19 in the United Kingdom1 
Key Inclusion Criterion

  • Hospitalized with suspected or laboratory-confirmed SARS-CoV-2 infection
Key Exclusion Criteria
  • Physician determination that risks of participation were too great based on patient’s medical history
  • An indication for corticosteroid therapy outside of the study
Interventions
  • DEX 6 mg IV or PO once daily plus SOC for up to 10 days or until discharge (n = 2,104)
  • SOC alone (n = 4,321)
Primary Endpoint
  • All-cause mortality at 28 days
Participant Characteristics

  • Mean age 66 years; 64% men; 73% White
  • 56% had ≥1 comorbidity; 24% with DM
  • 89% had laboratory-confirmed SARS-CoV-2 infection
  • Median of 7 days of DEX therapy
  • At randomization:
    • 16% received MV or ECMO
    • 60% required supplemental oxygen but not MV
    • 24% required no supplemental oxygen
  • Received RDV: <1% in both arms
  • Received tocilizumab or sarilumab: 2% in DEX arm vs. 3% in SOC arm
Primary Outcome
  • All-cause mortality at 28 days in DEX arm vs. SOC arm:
    • All patients: 23% vs. 26% (age-adjusted rate ratio 0.83; 95% CI, 0.75–0.93; P < 0.001)
    • Patients who required MV or ECMO at randomization: 29% vs. 41% (rate ratio 0.64; 95% CI, 0.51–0.81)
    • Patients who required supplemental oxygen but not MV at randomization: 23% vs. 26% (rate ratio 0.82; 95% CI, 0.72–0.94)
    • Patients who did not require supplemental oxygen at randomization: 18% vs. 14% (rate ratio 1.19, 95% CI, 0.92–1.55)
Key Limitations

  • Open-label study
  • Published data did not include results for key secondary endpoints (e.g., cause-specific mortality, need for renal replacement), AEs, and key subgroups (e.g., patients with comorbidities).
  • Patients who required supplemental oxygen (but not MV) had variable severity of illness. It is unclear whether all patients in this group benefited from DEX or whether benefit is restricted to those requiring higher levels of supplemental oxygen.
  • Patients aged >80 years were preferentially assigned to receive supplemental oxygen therapy (and not MV).
  • High mortality in this study may limit the generalizability of results to populations with a lower baseline mortality.
Interpretation
  • In hospitalized patients with severe COVID-19 who required supplemental oxygen, DEX reduced mortality at 28 days. The greatest benefit was seen in those receiving MV at randomization.
  • There was no survival benefit for DEX in patients who did not require supplemental oxygen at randomization.
CoDEX: Open-Label RCT of Dexamethasone in Patients With Moderate or Severe ARDS and COVID-19 in Brazil2
Key Inclusion Criteria

  • Confirmed or suspected SARS-CoV-2 infection
  • Received MV within 48 hours of meeting criteria for moderate to severe ARDS (PaO2/FiO2 ≤200 mm Hg)
Key Exclusion Criteria
  • Received immunosuppressive drugs in past 21 days
  • Death expected within 24 hours
Interventions
  • DEX 20 mg IV once daily for 5 days, then DEX 10 mg IV once daily for 5 days or until ICU discharge (n = 151)
  • SOC alone (n = 148)
Primary Endpoint 
  • Number of days alive and free from MV by Day 28
Key Secondary Endpoints 
  • All-cause mortality by Day 28
  • Number of ICU-free days by Day 28
  • Duration of MV by Day 28
  • Score on 6-point OS at Day 15
  • SOFA score at Day 7
Participant Characteristics

  • Mean age 61 years; 63% men
  • Comorbidities in DEX arm vs. SOC arm:
    • Obesity: 31% vs. 24%
    • DM: 38% vs. 47%
  • Vasopressor use: 66% in DEX arm vs. 68% in SOC arm
  • Mean PaO2/FiO2: 131 mm Hg in DEX arm vs. 133 mm Hg in SOC arm
  • Median of 10 days of DEX therapy
  • No patients received RDV or tocilizumab
  • 35% in SOC arm received corticosteroids for indications such as bronchospasm or septic shock
Primary Outcome
  • Mean number of days alive and free from MV by Day 28: 7 in DEX arm vs. 4 in SOC arm (P = 0.04)
Secondary Outcomes 
  • No differences between arms in all-cause mortality (56% in DEX arm vs. 62% in SOC arm), number of ICU-free days, duration of MV, or score on 6-point OS
  • Mean SOFA score at Day 7: 6.1 in DEX arm vs. 7.5 in SOC arm (P = 0.004)
Other Outcome
  • Post hoc analysis of probability of death or MV by Day 15: 68% in DEX arm vs. 80% in SOC arm (OR 0.46)
Key Limitations

  • Open-label study
  • Underpowered; enrollment stopped after release of data from the RECOVERY trial.
  • Patients discharged before 28 days were not followed for rehospitalization or mortality.
  • High mortality in this study may limit the generalizability of results to populations with a lower baseline mortality.
  • More than one-third of those randomized to receive SOC also received corticosteroids.
Interpretation 
  • Compared with SOC alone, DEX increased the number of days alive and free of MV over 28 days in patients with COVID-19 and moderate to severe ARDS.
Observational Cohort Study of Dexamethasone in Hospitalized Patients With COVID-19 Who Were Not on Intensive Respiratory Support in the United States3
Key Inclusion Criterion

  • Within 14 days of a positive test result for SARS-CoV-2 infection
Key Exclusion Criteria
  • Recent receipt of corticosteroids
  • Receipt of IRS (defined as HFNC oxygen, NIV, or MV) within 48 hours
  • Hospital LOS of <48 hours
Interventions
  • Corticosteroids (95% of patients received DEX) administered within 48 hours of admission (n = 7,507)
  • No corticosteroids administered (n = 7,433)
Primary Endpoint
  • All-cause mortality at 90 days
Participant Characteristics

  • Mean age 71 years; 95% men; 27% Black, 55% White
  • 77% did not receive IRS within 48 hours
  • 83% admitted within 1 day after positive SARS-CoV-2 test result
  • Median duration of DEX for patients who did not receive IRS: 5 days for patients who were not on supplemental oxygen at baseline vs. 6 days for patients on low-flow nasal cannula oxygen
  • Received RDV: 43% of those who received DEX vs. 13% of those who did not
  • Received anticoagulants: 46% of those who received DEX vs. 10% of those who did not
Primary Outcome
  • Risk of all-cause mortality at 90 days was higher in those who received DEX:
    • For combination of those not on supplemental oxygen and those on low-flow nasal cannula oxygen: HR 1.59; 95% CI, 1.39–1.81
    • For those not on supplemental oxygen: HR 1.76; 95% CI, 1.47–2.12
    • For those on low-flow nasal cannula oxygen: HR 1.08; 95% CI, 0.86–1.36
Key Limitations

  • Retrospective observational study
  • Because nearly all patients on MV or HFNC oxygen received DEX, analysis was restricted to patients who did not receive IRS (i.e., those who received no supplemental oxygen or only low-flow nasal cannula oxygen).
  • There were differences between the arms in other therapies received. The investigators attempted to account for this using different approaches (e.g., propensity scoring, weighted analyses, subgroup/sensitivity analyses).
Interpretation
  • In hospitalized patients with COVID-19, the use of DEX was not associated with a reduction in mortality among those who received low-flow nasal cannula oxygen during the first 48 hours after admission, but it was associated with increased mortality among those who received no supplemental oxygen during the first 48 hours after admission.
COVID STEROID 2: Blinded RCT of Dexamethasone 12 mg Versus 6 mg in Hospitalized Adults With COVID-19 and Severe Hypoxemia in Denmark, India, Sweden, and Switzerland4,5 
Key Inclusion Criteria
  • Confirmed SARS-CoV-2 infection
  • Requiring oxygen ≥10 L/min, NIV, CPAP, or MV
 Key Exclusion Criteria
  • Treated with DEX >6 mg (or equivalent)
  • Treated with a corticosteroid within past 5 days
  • Invasive fungal infection or active TB
Interventions
  • DEX 12 mg IV once daily for up to 10 days (n = 497)
  • DEX 6 mg IV once daily for up to 10 days (n = 485)
Primary Endpoint
  • Number of days alive without life support (MV, circulatory support, or kidney replacement therapy) at 28 days
Key Secondary Endpoints
  • Number of days alive without life support at 90 days
  • Number of days alive and out of hospital at 90 days
  • Mortality at 90 days
  • Mortality at 28 days
  • SAEs at 28 days
Participant Characteristics

  • Median age 65 years; 31% women
  • DM: 27% in 12 mg arm vs. 34% in 6 mg arm
  • Median of 7 days from symptom onset to hospitalization in both arms
  • Received ICU care: 78% in 12 mg arm vs. 81% in 6 mg arm
  • Oxygen requirements:
    • 54% on oxygen via nasal cannula or face mask (median flow rate 23 L/min)
    • 25% on NIV
    • 21% on MV
  • 63% received RDV; 12% received IL-6 inhibitors or JAK inhibitors
  • Median of 7 days of DEX therapy in both arms
Primary Outcome
  • Median number of days alive without life support at 28 days: 22.0 in 12 mg arm vs. 20.5 in 6 mg arm (adjusted mean difference 1.3 days; 95% CI, 0.0–2.6; P = 0.07)
    • 63.9% Bayesian probability of clinically important benefit and 0.3% Bayesian probability of clinically important harm for DEX 12 mg
Secondary Outcomes
  • At 90 days:
    • Median number of days alive without life support: 84 in 12 mg arm vs. 80 in 6 mg arm (P = 0.15)
    • Median number of days alive and out of hospital: 62 in 12 mg arm vs. 48 in 6 mg arm (P = 0.09)
    • Mortality: 32% in 12 mg arm vs. 38% in 6 mg arm (adjusted relative risk 0.87; 99% CI, 0.70–1.07; P = 0.09)
  • At 28 days:
    • Mortality: 27% in 12 mg arm vs. 32% in 6 mg arm (adjusted relative risk 0.86; 99% CI, 0.68–1.08; P = 0.10)
    • SAEs, including septic shock and invasive fungal infections: 11% in 12 mg arm vs. 13% in 6 mg arm (adjusted relative risk 0.83; 99% CI, 0.54–1.29; P = 0.27)
Key Limitation

  • The randomized intervention period was <10 days in some patients because the trial allowed up to 4 days of DEX before enrollment.
Interpretation
  • Among patients with COVID-19 and severe hypoxemia, the use of DEX 12 mg once daily did not result in more days alive without life support at 28 days than DEX 6 mg once daily.
CAPE COVID: Double-Blind RCT of Hydrocortisone Among Critically Ill Patients With COVID-19 in France6
Key Inclusion Criteria

  • Laboratory-confirmed SARS-CoV-2 infection or radiographically suspected COVID-19 with ≥1 of the following:
    • MV with PEEP ≥5 cm H2O
    • PaO2/FiO2 <300 mm Hg and FiO2 ≥50% on HFNC
    • PaO2/FiO2 <300 mm Hg on reservoir mask oxygen
    • Pulmonary severity index score >130
Key Exclusion Criteria
  • Septic shock
  • Do-not-intubate orders
Interventions
  • Continuous IV infusion of hydrocortisone 200 mg per day for 7 days, then 100 mg per day for 4 days, then 50 mg per day for 3 days. If patient improved by Day 4, then IV infusion of hydrocortisone 200 mg per day for 4 days, then 100 mg per day for 2 days, then 50 mg per day for 2 days (n = 76).
  • Placebo (n = 73)
Primary Endpoint
  • Treatment failure (death or dependency on MV or high-flow oxygen) by Day 21
Key Secondary Endpoints
  • Need for intubation, prone positioning, ECMO, or inhaled nitric oxide
  • Nosocomial infection by Day 28
  • Clinical status on Day 21, as measured by a 5-item scale:
    • Death
    • In ICU and on MV
    • Required high-flow oxygen therapy
    • Required low-flow oxygen therapy
    • Discharged from ICU
Participant Characteristics

  • Mean age 62 years; 70% men; median BMI 28
  • 96% had laboratory-confirmed SARS-CoV-2 infection
  • Median symptom duration of 9–10 days
  • 81% required MV at baseline
  • Received vasopressors: 24% in hydrocortisone arm vs. 18% in placebo arm
  • <5% received RDV or tocilizumab
  • Median duration of treatment with study drug: 11 days in hydrocortisone arm vs. 13 days in placebo arm (P = 0.25)
Primary Outcome
  • Treatment failure by Day 21: 42% in hydrocortisone arm vs. 51% in placebo arm (P = 0.29)
Secondary Outcomes
  • No difference between arms in need for intubation or prone positioning (too few patients received ECMO or inhaled nitric oxide for comparisons)
  • Among patients who did not require MV at baseline, 50% in hydrocortisone arm vs. 75% in placebo arm required subsequent intubation
  • No difference between arms in proportion of patients with nosocomial infection by Day 28
  • No difference between arms in clinical status on Day 21, but 15% died in hydrocortisone arm vs. 27% in placebo arm (P = 0.06)
  • Discharged from ICU by Day 21: 57% in hydrocortisone arm vs. 44% in placebo arm; 23% in both arms still required MV
Key Limitations

  • Underpowered; enrollment stopped after release of data from the RECOVERY trial, resulting in limited power to detect differences between arms.
  • Limited information about comorbidities
Interpretation
  • The use of hydrocortisone did not reduce the proportion of patients with COVID-19 and acute respiratory failure who experienced treatment failure by Day 21.
REMAP-CAP: Randomized, Open-Label, Adaptive Trial of Hydrocortisone in Patients With Severe COVID-197
Key Inclusion Criteria

  • Presumed or laboratory-confirmed SARS-CoV-2 infection
  • ICU admission for respiratory or cardiovascular support
Key Exclusion Criteria
  • Presumed imminent death
  • Systemic corticosteroid use
  • >36 hours since ICU admission
Interventions
  • Hydrocortisone 50 mg IV every 6 hours for 7 days (n = 137)
  • Shock-dependent hydrocortisone 50 mg IV every 6 hours for duration of shock for up to 28 days (n = 146)
  • No hydrocortisone (n = 101)
Primary Endpoint
  • Number of days free from respiratory and cardiovascular support by Day 21
Key Secondary Endpoint
  • In-hospital mortality
Participant Characteristics

  • Mean age 60 years; 71% men; 53% White
  • Mean BMI range of 29.7–30.9 for the 3 arms
  • 50% to 64% required MV
Primary Outcome
  • No difference between arms in median number of organ support-free days at Day 21 (0 in each arm)
  • Median adjusted ORs for primary outcome for hydrocortisone arms compared to no hydrocortisone arm:
    • OR 1.43 (95% CrI, 0.91–2.27) with 93% Bayesian probability of superiority for fixed-dose hydrocortisone arm
    • OR 1.22 (95% CrI, 0.76–1.94) with 80% Bayesian probability of superiority for shock-dependent hydrocortisone arm
Key Secondary Outcome
  • No difference between arms in in-hospital mortality (30% in fixed-dose hydrocortisone arm vs. 26% in shock-dependent hydrocortisone arm vs. 33% in no hydrocortisone arm)
Key Limitations

  • Open-label study
  • Enrollment stopped after release of data from the RECOVERY trial.
Interpretation
  • The use of hydrocortisone did not increase the median number of organ support-free days in either the fixed-dose or the shock-dependent hydrocortisone arms, although early termination limited the study’s power to detect differences between the study arms.
Single-Blind RCT of Methylprednisolone in Hospitalized Patients With COVID-19 Pneumonia in China8
Key Inclusion Criteria

  • Laboratory-confirmed SARS-CoV-2 infection
  • Pneumonia confirmed by chest CT scan
  • Hospitalized on general ward for <72 hours
 Key Exclusion Criteria
  • Severe immunosuppression
  • Corticosteroid use for other diseases
Interventions
  • Methylprednisolone 1 mg/kg per day IV for 7 days (n = 43)
  • Saline (n = 43)
Primary Endpoint
  • Clinical deterioration at 14 days
Key Secondary Endpoints
  • Clinical cure at 14 days
  • Time to clinical cure
  • ICU admission
  • In-hospital mortality
  • Number of days hospitalized
Participant Characteristics

  • Mean age 56 years; 48% men
  • Median of 8 days from symptom onset to randomization
  • At randomization, 71% were receiving oxygen via nasal cannula
Primary Outcome
  • Clinical deterioration at 14 days: 4.8% in both arms (OR 1.0; 95% CI, 0.134–7.442; P = 1.00)
Secondary Outcomes
  • No differences (all P > 0.05) between methylprednisolone arm and placebo arm for:
    • Clinical cure at 14 days: 51% vs. 58%
    • Median number of days to clinical cure: 14 vs. 12
    • ICU admission: 4.8% in both arms
    • In-hospital mortality: 0% vs. 2.3%
    • Median number of days hospitalized: 17 vs. 13
Key Limitations

  • Small sample size
  • Terminated early because of decreasing incidence of COVID-19 pneumonia at study sites
Interpretation
  • The incidence of clinical deterioration did not differ between the methylprednisolone and placebo arms.
Single-Blind RCT of 3 Doses of Dexamethasone in Hospitalized Patients With Moderate to Severe COVID-19 in Iran9
Key Inclusion Criteria

  • PCR-confirmed SARS-CoV-2 infection or CT scan showing lung involvement
  • Moderate or severe COVID-19
  • Requirement for supplemental oxygen
Key Exclusion Criteria
  • Uncontrolled DM
  • Active fungal or parasitic infection
  • On MV or receiving vasopressor therapy
Interventions
  • Low dose: DEX 8 mg IV once daily for up to 10 days (n = 47)
  • Intermediate dose: DEX 8 mg IV twice daily for up to 10 days (n = 40)
  • High dose: DEX 8 mg IV 3 times a day for up to 10 days (n = 46)
Primary Endpoint
  • Time to clinical response, as measured by an OS
Key Secondary Endpoints
  • Mortality at 60 days
  • Occurrence of AEs
Participant Characteristics

  • Mean age: 59 years in low-dose arm vs. 59 years in intermediate-dose arm vs. 56 years in high-dose arm
  • 50% men
  • 23% with DM
  • 75% received RDV
Primary Outcome
  • Mean number of days to clinical response: 4.3 in low-dose arm vs. 5.3 in intermediate-dose arm vs. 6.1 in high-dose arm (P = 0.025)
Secondary Outcomes
  • Mortality at 60 days: 17% in low-dose arm vs. 30% in intermediate-dose arm vs. 41% in high-dose arm (P = 0.06)
  • AEs (leukocytosis, hyperglycemia, and secondary infections) occurred more frequently in intermediate-dose and high-dose arms than in low-dose arm; however, this result was not statistically significant.
Key Limitation

  • Small sample size
Interpretation
  • The time to clinical response was significantly shorter in the low-dose DEX arm than in the intermediate- or high-dose arms. Patients in the low-dose arm had a higher probability of survival than those in the high-dose arm.
Open-Label Randomized Trial of High-Dose Versus Low-Dose Dexamethasone in Patients With COVID-19–Related ARDS in Argentina10
Key Inclusion Criteria

  • Laboratory-confirmed SARS-CoV-2 infection
  • ARDS
  • On MV for <72 hours
Key Exclusion Criteria
  • Presumed imminent death
  • Immunosuppression
  • Treatment with glucocorticoids
Interventions
  • High dose: DEX 16 mg IV once daily for 5 days, then DEX 8 mg IV once daily for 5 days (n = 49)
  • Low dose: DEX 6 mg IV once daily for 10 days (n = 49)
Primary Endpoints
  • Number of ventilator-free days by Day 28
  • Time to discontinuation of MV
Key Secondary Endpoint
  • All-cause mortality by Day 28 and Day 90
Participant Characteristics

  • Mean age: 60 years in high-dose arm vs. 63 years in low-dose arm
  • 30% women
Primary Outcomes
  • Median number of ventilator-free days by Day 28: 0 for both arms (P = 0.23)
  • No difference between arms in mean duration of MV by Day 28 (19 ±18 days in high-dose arm vs. 25 ±22 days in low-dose arm; P = 0.078). Cumulative hazard of successful discontinuation from MV was greater in high-dose arm than in low-dose arm (adjusted subdistribution HR 1.84; 95% CI, 1.31–2.5; P < 0.001).
Secondary Outcome
  • All-cause mortality:
    • By Day 28: 41% in high-dose arm vs. 39% in low-dose arm (P > 0.999)
    • By Day 90: 47% in both arms (P > 0.999)
Key Limitations

  • Small, open-label study
  • Trial was prematurely terminated due to low enrollment rate.
Interpretation
  • The use of a higher dose of DEX did not increase the median number of ventilator-free days in patients with ARDS due to COVID-19. However, the higher dose shortened the time to discontinuation of MV.
COVIDICUS: RCT of High-Dose Dexamethasone Versus Standard of Care Dexamethasone in Patients With COVID-19–Related Respiratory Failure in the ICU in France11
Key Inclusion Criteria

  • Laboratory-confirmed or suspected SARS-CoV-2 infection
  • Admitted to ICU in past 48 hours
  • Respiratory failure (PaO2 <70 mm Hg, SpO2 <90% on room air, >30 breaths/min, labored breathing, respiratory distress, or need for oxygen ≥6 L/min)
Key Exclusion Criteria
  • Decision to limit life-sustaining treatment
  • Therapy with ≥0.5 mg/kg per day of prednisone equivalent for ≥3 weeks
  • Active and untreated bacterial, fungal, or parasitic infection
Interventions
  • High dose: DEX 20 mg IV once daily for 5 days, then DEX 10 mg IV once daily for 5 days (n = 270)
  • SOC: DEX 6 mg IV once daily for 10 days (n = 239) or placebo (n = 37)
Primary Endpoint
  • All-cause mortality by Day 60
Participant Characteristics

  • Median age 67 years; 76% men
  • Median of 9 days from symptom onset to randomization
  • 81% had ≥1 comorbidity
  • 17% received RDV; <1% received tocilizumab
Primary Outcome
  • All-cause mortality by Day 60: 26% in high-dose arm vs. 27% in SOC arm (HR 0.96; 95% CI, 0.69–1.33; P = 0.79)
Key Limitation

  • Comparator arm was initially a placebo but was changed to a standard dose of DEX after the RECOVERY trial results were released.
Interpretation
  • Among ICU patients with COVID-19–related respiratory failure, high-dose DEX did not significantly improve 60-day survival.
Open-Label RCT of Dexamethasone 6 mg or 20 mg in Hospitalized Adults With COVID-19 in the United States12
Key Inclusion Criteria

  • PCR-confirmed SARS-CoV-2 infection
  • Need for supplemental oxygen
Key Exclusion Criteria
  • Use of corticosteroids for >48 hours
  • Death expected within 24 hours
Interventions
  • High dose: DEX 20 mg daily for 5 days, then DEX 10 mg daily for 5 days (n = 52)
  • Low dose: DEX 6 mg daily for 10 days (n = 55)
Primary Endpoint
  • Clinical improvement by Day 28, as measured by a WHO OS
Secondary Endpoints
  • Mortality by Day 28
  • Number of ICU-free days by Day 28
  • Number of ventilator-free days by Day 28
Participant Characteristics

  • Mean age: 58 years in low-dose arm vs. 56 years in high-dose arm
  • 75% men; 50% White
  • 36% with obesity; 29% with DM; 8% partially or fully vaccinated
  • Received tocilizumab or baricitinib: 40% in low-dose arm vs. 21% in high-dose arm (P = 0.035)
Primary Outcome
  • Clinical improvement by Day 28: 78% of low-dose arm vs. 71% of high-dose arm (OR 1.45; 95% CI, 0.55–3.86; P = 0.40)
Secondary Outcomes
  • Mortality by Day 28 in low-dose arm vs. high-dose arm:
    • All patients: 5 (9%) vs. 11 (21%; P = 0.08)
    • Patients on HFNC oxygen or NIV: 0 of 15 vs. 6 of 14 (P = 0.025)
  • No difference between arms in median number of ICU-free days or ventilator-free days by Day 28
Key Limitations

  • Small, open-label study
  • Enrollment halted after interim analysis showed higher mortality in subgroup of patients who were on HFNC oxygen or NIV in the high-dose arm.
  • More patients in the low-dose arm received additional immunomodulators.
Interpretation
  • The use of high-dose DEX did not improve clinical outcomes in hospitalized patients with COVID-19, and it may have increased mortality among patients on HFNC oxygen or NIV.

References

  1. RECOVERY Collaborative Group, Horby P, Lim WS, et al. Dexamethasone in hospitalized patients with COVID-19. N Engl J Med. 2021;384(8):693-704. Available at: https://www.ncbi.nlm.nih.gov/pubmed/32678530.
  2. Tomazini BM, Maia IS, Cavalcanti AB, et al. Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX randomized clinical trial. JAMA. 2020;324(13):1307-1316. Available at: https://www.ncbi.nlm.nih.gov/pubmed/32876695.
  3. Crothers K, DeFaccio R, Tate J, et al. Dexamethasone in hospitalised COVID-19 patients not on intensive respiratory support. Eur Respir J. 2022;60(1):2102532. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34824060.
  4. COVID STEROID 2 Trial Group, Munch MW, Myatra SN, et al. Effect of 12 mg vs 6 mg of dexamethasone on the number of days alive without life support in adults with COVID-19 and severe hypoxemia: the COVID STEROID 2 randomized trial. JAMA. 2021;326(18):1807-1817. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34673895.
  5. Granholm A, Munch MW, Myatra SN, et al. Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial. Intensive Care Med. 2022;48(1):45-55. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34757439.
  6. Dequin PF, Heming N, Meziani F, et al. Effect of hydrocortisone on 21-day mortality or respiratory support among critically ill patients with COVID-19: a randomized clinical trial. JAMA. 2020;324(13):1298-1306. Available at: https://www.ncbi.nlm.nih.gov/pubmed/32876689.
  7. Angus DC, Derde L, Al-Beidh F, et al. Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial. JAMA. 2020;324(13):1317-1329. Available at: https://www.ncbi.nlm.nih.gov/pubmed/32876697.
  8. Tang X, Feng YM, Ni JX, et al. Early use of corticosteroid may prolong SARS-CoV-2 shedding in non-intensive care unit patients with COVID-19 pneumonia: a multicenter, single-blind, randomized control trial. Respiration. 2021;100(2):116-126. Available at: https://www.ncbi.nlm.nih.gov/pubmed/33486496.
  9. Toroghi N, Abbasian L, Nourian A, et al. Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial. Pharmacol Rep. 2022;74(1):229-240. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34837648.
  10. Maskin LP, Bonelli I, Olarte GL, et al. High- versus low-dose dexamethasone for the treatment of COVID-19-related acute respiratory distress syndrome: a multicenter, randomized open-label clinical trial. J Intensive Care Med. 2022;37(4):491-499. Available at: https://www.ncbi.nlm.nih.gov/pubmed/34898320.
  11. Bouadma L, Mekontso-Dessap A, Burdet C, et al. High-dose dexamethasone and oxygen support strategies in intensive care unit patients with severe COVID-19 acute hypoxemic respiratory failure: the COVIDICUS randomized clinical trial. JAMA Intern Med. 2022;182(9):906-916. Available at: https://www.ncbi.nlm.nih.gov/pubmed/35788622.
  12. Wu H, Daouk S, Kebbe J, et al. Low-dose versus high-dose dexamethasone for hospitalized patients with COVID-19 pneumonia: a randomized clinical trial. PLoS One. 2022;17(10):e0275217. Available at: https://pubmed.ncbi.nlm.nih.gov/36190994/.