Category: Drugs and Dosage
DOAC list , updates
Direct Oral Anticoagulants (DOACs) in 2025: –Apixaban (Factor Xa inhibitor) –Rivaroxaban (Factor Xa inhibitor) –Edoxaban(Factor Xa inhibitor)Dabigatran (Direct thrombin inhibitor) –Betrixaban (Factor Xa inhibitor, approved for extended VTE prophylaxis) Apixaban (Eliquis)–Onset: Rapid, with peak plasma concentrations reached in 3–4 hours. –Action: Direct factor Xa inhibitor, preventing clot formation. –Side Effects: – Bleeding (most common, including…
SGLT-2 inhibitor for diabetes
Mechanism of Action: SGLT2 inhibitors block the reabsorption of glucose in the proximal tubule, increasing urinary glucose excretion (UGE) and lowering plasma glucose levels. They also have beneficial effects on blood pressure, body weight, and cardiovascular outcomes. – Dosing: Empagliflozin: 10–25 mg once daily (start at 10 mg, max 25 mg). – Dapagliflozin: 5–10 mg…
New drugs for Migraine
Gepants (CGRP receptor antagonists)Names: Rimegepant (Nurtec ODT), Ubrogepant (Ubrelvy) Mechanism: Block calcitonin gene-related peptide (CGRP) receptors, reducing inflammation and pain. – Dosage:Rimegepant: 75 mg orally as needed for acute migraine. – Ubrogepant: 50–100 mg orally as needed for acute migraine. – Rationale: Effective for moderate to severe migraines, with fewer side effects than triptans. –…