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Cyanide poisoning Shortnote
Quote from สุขภาพและความงาม on เมษายน 30, 2023, 2:44 pmAssistant professor of criminal justice Chi-Chung (Jorn) Yu is studying a new biomarker for cyanide poisoning, which may extend its detection window in death investigations by weeks, if not months.
Unless cyanide is found at the time of death on the mouth or nose, elevated cyanide concentration can only be found for up to two days under current toxicological testing, according to Yu.
A recent study in Yu’s laboratory found that a biomarker, ACTA (2-aminothiazoline-4-carboxylic acid), was found significantly increased in liver samples following a sub-lethal dose of cyanide.
They also found that the substance could serve as a stable biomarker for a longer period of time.
“We think this is proving to be a reasonable marker for cyanide poisoning,” Yu said. “We want to be able to extend the detection window up to weeks or even months.”
Forensic Research Extends Detection Of Cyanide Poisoning
Jan. 9, 2012
Assistant professor of criminal justice Chi-Chung (Jorn) Yu is studying a new biomarker for cyanide poisoning, which may extend its detection window in death investigations by weeks, if not months.
Unless cyanide is found at the time of death on the mouth or nose, elevated cyanide concentration can only be found for up to two days under current toxicological testing, according to Yu.
A recent study in Yu’s laboratory found that a biomarker, ACTA (2-aminothiazoline-4-carboxylic acid), was found significantly increased in liver samples following a sub-lethal dose of cyanide.
They also found that the substance could serve as a stable biomarker for a longer period of time.
“We think this is proving to be a reasonable marker for cyanide poisoning,” Yu said. “We want to be able to extend the detection window up to weeks or even months.”
Forensic Research Extends Detection Of Cyanide Poisoning
Jan. 9, 2012
Quote from สุขภาพและความงาม on เมษายน 30, 2023, 2:45 pmIn the investigation of deaths, a bitter almond odor emanating from the victim and the presence of pink lividity during postmortem examination are two common indicators of acute cyanide poisoning. Alkali burns of the gastrointestinal tract often can be observed during autopsy in cases where cyanide salts have been ingested, Yu said.
“Due to the relatively short half-life of cyanide—from minutes to hours depending on the matrix—toxicological detection of cyanide to confirm cyanide poisoning may only be feasible within the first few hours following exposure,” he said. “Moreover, the volatility and reactivity of cyanide leaves direct measurements highly susceptible to errors introduced during the sample collection and separation step.
“Cyanide levels in blood samples taken at autopsy the next day have been reported to decrease by approximately 79 percent. Postmortem formation of cyanide may also occur and complicate the interpretation of cyanide results,” he said.
In the investigation of deaths, a bitter almond odor emanating from the victim and the presence of pink lividity during postmortem examination are two common indicators of acute cyanide poisoning. Alkali burns of the gastrointestinal tract often can be observed during autopsy in cases where cyanide salts have been ingested, Yu said.
“Due to the relatively short half-life of cyanide—from minutes to hours depending on the matrix—toxicological detection of cyanide to confirm cyanide poisoning may only be feasible within the first few hours following exposure,” he said. “Moreover, the volatility and reactivity of cyanide leaves direct measurements highly susceptible to errors introduced during the sample collection and separation step.
“Cyanide levels in blood samples taken at autopsy the next day have been reported to decrease by approximately 79 percent. Postmortem formation of cyanide may also occur and complicate the interpretation of cyanide results,” he said.
Quote from สุขภาพและความงาม on เมษายน 30, 2023, 2:48 pmCan cyanide cause a human dead in seconds?
Yes!
Cyanide is a mitochondrial toxin that is among the most rapidly lethal poisons known. Used in both ancient and modern times as a method of execution, cyanide causes death within minutes to hours of exposure.
HPIM : Cyanide toxicity cause Histotoxic Hypoxemia .It break the electron transport chain. It causes coma followed by cardiac arrest and death
Can you survive exposure to cyanide?Yes!Levels of 0.5–1 mg/L are mild, 1–2 mg/L are moderate, 2–3 mg/L are severe, and greater than 3 mg/L generally result in death. If exposure is suspected, the person should be removed from the source of the exposure and decontaminated. Treatment involves supportive care and giving the person 100% oxygen.
Can cyanide cause a human dead in seconds?
Yes!
Cyanide is a mitochondrial toxin that is among the most rapidly lethal poisons known. Used in both ancient and modern times as a method of execution, cyanide causes death within minutes to hours of exposure.
HPIM : Cyanide toxicity cause Histotoxic Hypoxemia .It break the electron transport chain. It causes coma followed by cardiac arrest and death
Quote from สุขภาพและความงาม on เมษายน 30, 2023, 2:53 pmWhat’s worse than cyanide?Ricin is much more poisonous than potassium cyanide. Doses of ricin the size of a matchhead are sufficient to kill an adult human being. Ricin is made from castor beans, the fruit of the castor-oil plant (Ricinus communis), which grows in the tropics and subtropics all over the world.What foods cause cyanide? Cyanide was called Natural Toxin in foodCassava, sorghum, stone fruits, bamboo roots and almonds are especially important foods containing cyanogenic glycosides. The potential toxicity of a cyanogenic plant depends primarily on the potential that its consumption will produce a concentration of cyanide that is toxic to exposed humans.
Quote from สุขภาพและความงาม on เมษายน 30, 2023, 8:05 pmCyanide (CN‐) is the salt of hydrogen cyanide (HCN). Due to its extreme toxicity, cyanide is one of the most potent poisons; its LD50 is approximately 1–2 mg/kg of body weight [1]. Potassium cyanide (KCN) and sodium cyanide (NaCN) are the most common ingested forms of cyanide. Once the cyanide ion reaches the extremely acidic environment of the stomach, CN‐ is converted to HCN, which passively diffuses across the gastric membrane [2].
After oral intake, the inhibition of psychophysical abilities occurs within a few seconds to 1 or 2 min. In some cases, a latency interval of 5–10 min or longer has been reported. Soon after loss of consciousness, convulsions, hypotension, apnea, shock, and, eventually, death from cellular asphyxia have been observed [3].
Cyanide is a poison widely used for homicide or suicide. Worldwide, recent fatal and non‐fatal cases of cyanide poisoning have been reported In Seoul (Korea), 255 deaths from cyanide poisoning were described between 2005 and 2010; of these, 97.3% were suicides. The most frequent route of administration was oral one (98.8%)
Cyanide is a relatively easy‐to‐obtain poison. In nature, cyanogenic glycosides present in various plants release hydrogen cyanide by hydrolysis. Amygdalin is the most common cyanogenic glycoside; it is contained in seeds or kernels of bitter almonds, apricots, peaches, cherries, and plums. It is also present in the leaves of the Prunus laurocerasus (also known as Cherry Laurel) and in other common plants [12].
It is used as fumigant, rodenticide, in agricultural products [13] and in jewelry electroplating [14]. Cyanide is easily available on the website , especially in the so‐called “Deep Web” and “Dark Web”
Moreover, hydrogen cyanide is a possible product of combustion processes: it is present in the exhaust of internal combustion engines, in cigarette smoke, and in fumes derived from the fusion of plastic materials containing nitrogen
Cyanide (CN‐) is the salt of hydrogen cyanide (HCN). Due to its extreme toxicity, cyanide is one of the most potent poisons; its LD50 is approximately 1–2 mg/kg of body weight [1]. Potassium cyanide (KCN) and sodium cyanide (NaCN) are the most common ingested forms of cyanide. Once the cyanide ion reaches the extremely acidic environment of the stomach, CN‐ is converted to HCN, which passively diffuses across the gastric membrane [2].
After oral intake, the inhibition of psychophysical abilities occurs within a few seconds to 1 or 2 min. In some cases, a latency interval of 5–10 min or longer has been reported. Soon after loss of consciousness, convulsions, hypotension, apnea, shock, and, eventually, death from cellular asphyxia have been observed [3].
Cyanide is a poison widely used for homicide or suicide. Worldwide, recent fatal and non‐fatal cases of cyanide poisoning have been reported In Seoul (Korea), 255 deaths from cyanide poisoning were described between 2005 and 2010; of these, 97.3% were suicides. The most frequent route of administration was oral one (98.8%)
Cyanide is a relatively easy‐to‐obtain poison. In nature, cyanogenic glycosides present in various plants release hydrogen cyanide by hydrolysis. Amygdalin is the most common cyanogenic glycoside; it is contained in seeds or kernels of bitter almonds, apricots, peaches, cherries, and plums. It is also present in the leaves of the Prunus laurocerasus (also known as Cherry Laurel) and in other common plants [12].
It is used as fumigant, rodenticide, in agricultural products [13] and in jewelry electroplating [14]. Cyanide is easily available on the website , especially in the so‐called “Deep Web” and “Dark Web”
Moreover, hydrogen cyanide is a possible product of combustion processes: it is present in the exhaust of internal combustion engines, in cigarette smoke, and in fumes derived from the fusion of plastic materials containing nitrogen